Calcium May Increase Risk of Heart Attack
Sunday, September 19th, 2010Calcium supplements are commonly prescribed to prevent and manage osteoporosis.
A few randomized trials on calcium supplements have shown an increased risk of cardiovascular adverse events in women taking calcium supplements. (Reid et al Am J Med 2006;119:777-85 and Bolland et al BMJ 2008;336:262-6)
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A newly published meta analysis of clinical trials of calcium supplements (Bolland et al BMJ 2010 341 c3691) shows that calcium intake increases the risk of heart attacks (myocardial infarction) by 30%.
In this meta analysis, 15 trials were eligible for inclusion, five with
patient level data (8151 participants, median follow-up 3.6 years, interquartile range 2.7-4.3 years) and 11 with trial level data (11 921 participants, mean duration 4.0 years). The number of subjects in the analysis totalled 12,000 participants.
In the five studies contributing patient level data, 143 people allocated to calcium had a myocardial infarction compared with 111 allocated to placebo (hazard ratio 1.31, 95% confidence interval 1.02 to 1.67, P=0.035)
The authors conclude that calcium supplements (without co-administered vitamin D) are associated with an increased risk of myocardial infarction. As calcium supplements are widely used these modest increases in risk of cardiovascular disease might translate into a large burden of disease in the population.
Studies on Vitamin D with or without calcium are also warranted.
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